Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 18/20 | 0.53 |
| ▸ | TPSD1 | Q9BZJ3 | 15/20 | 0.53 |
| ▸ | TPSG1 | Q9NRR2 | 15/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.42 |
| ▸ | F2 | P00734 | 5/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498048 | 0.84 | TPSAB1 (0.45) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7503667 | 0.74 | F2 (0.58) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7579428 | 0.74 | TPSAB1 (0.41) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7445239 | 0.74 | TPSAB1 (0.67) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7543760 | 0.74 | TPSAB1 (0.37) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7450417 | 0.73 | TPSAB1 (0.59) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7504599 | 0.73 | TPSAB1 (0.52) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7447693 | 0.71 | TPSAB1 (0.78) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL7444123 | 0.70 | TPSAB1 (0.72) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7424872 | 0.70 | TPSAB1 (0.53) | TPSAB1TPSD1TPSG1PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |