SCHEMBL7543853

SCHEMBL7543853

Cn1c(C(F)(F)F)cc(C#N)c1-c1ccc(Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.44
ALDH1A1 P00352 4/20 0.44
GAA P10253 3/20 0.44
MEN1 O00255 2/20 0.44
LMNA P02545 2/20 0.44
HPGD P15428 2/20 0.44
KMT2A Q03164 2/20 0.44
AR P10275 6/20 0.43
MAOA P21397 3/20 0.41
TDP1 Q9NUW8 1/20 0.38
PGR P06401 1/20 0.38
HTT P42858 2/20 0.37
GLA P06280 1/20 0.37
CRHBP P24387 1/20 0.37
CRHR2 Q13324 1/20 0.37
TP53 P04637 2/20 0.37
CNR1 P21554 1/20 0.36
MAPT P10636 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9191382 0.86 AR (0.38) KDM4EALDH1A1GAAMEN1LMNA
SCHEMBL2480602 0.82 AR (0.43) KDM4EALDH1A1GAAMEN1LMNA
SCHEMBL7818938 0.82 KDM4E (0.47) KDM4EALDH1A1GAAMEN1LMNA
SCHEMBL9196748 0.79 HSD11B1 (0.42) ARPGR
SCHEMBL9057667 0.79 CNR1 (0.42) KDM4EALDH1A1GAAMEN1LMNA
SCHEMBL8532395 0.78 KDM4E (0.38) KDM4EALDH1A1GAAMEN1LMNA
Hydrochloric Acid SCHEMBL28752946 0.77 KDM4E (0.37) KDM4EALDH1A1GAAMEN1LMNA
SCHEMBL7816493 0.76 CNR1 (0.56) KDM4EALDH1A1HPGDARCNR1
SCHEMBL8976138 0.71 ALDH1A1 (0.41) KDM4EALDH1A1GAAMEN1LMNA
SCHEMBL9423766 0.69 S1PR3 (0.33) KDM4EALDH1A1GAAMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111253821-B High-solid-content copper-free linear self-polishing marine antifouling paint 浙江省海洋开发研究院 2022-03-22 CN claimed
CN-111253821-A High-solid-content copper-free linear self-polishing marine antifouling paint 浙江省海洋开发研究院 2020-06-09 CN claimed
CN-115850646-B Waterborne polyurethane for marine antifouling and preparation method thereof 嘉兴学院 2024-01-26 CN disclosed
CN-115850646-A Waterborne polyurethane for marine antifouling and preparation method thereof 嘉兴学院 2023-03-28 CN disclosed
CN-111253821-B High-solid-content copper-free linear self-polishing marine antifouling paint 浙江省海洋开发研究院 2022-03-22 CN disclosed
CN-111253821-A High-solid-content copper-free linear self-polishing marine antifouling paint 浙江省海洋开发研究院 2020-06-09 CN disclosed
EP-0826667-B1 2 Aryl 5 (trifluoromethyl) 2 pyrroline compounds and process for the manufacture of insecticidal, 2 aryl 1 (alkoxymethyl) 4 halo 5 (trifluoromethyl) pyrroles BASF AG (DE) 2002-10-30 EP disclosed
EP-0816337-B1 A process for the manufacture of 2 aryl 5 perfluoroalkylpyrrole derivatives and intermediates useful therefor BASF AG (DE) 2001-08-08 EP disclosed
EP-0492171-B1 4-Chloro-1-(ethoxymethyl)-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile, and its use as insecticide, nematocide and acaricide AMERICAN CYANAMID CO (US) 2000-08-02 EP disclosed
EP-0492093-B1 Process for the preparation of 2-aryl 1-substituted-5-(trifluoromethyl)pyrrole compounds useful as insecticidal, acaricidal and nematocidal agents and as intermediates for the manufacture of said agents AMERICAN CYANAMID CO (US) 1999-03-17 EP disclosed
US-5777132-A CHEMICAL CONDENSATION OF NITRILE AMIDE WITH DIENOPHILE AMERICAN CYANAMID COMPANY (US) 1998-07-07 US disclosed
US-5449789-A Debrominative chlorination of pyrroles AMERICAN CYANAMID COMPANY (US) 1995-09-12 US disclosed
US-5380876-A 2-aryl-5(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles AMERICAN CYANAMID COMPANY (US) 1995-01-10 US disclosed
EP-0600157-A1 Debrominative chlorination of pyrroles AMERICAN CYANAMID COMPANY (US) 1994-06-08 EP disclosed
US-5225568-A Process for the preparation of insecticidal, acaricidal and nematicidal 2-aryl-3-substituted-5-(trifluoromethyl)pyrrole compounds AMERICAN CYANAMID COMPANY (US) 1993-07-06 US disclosed
US-5144041-A Process for the preparation of 2-aryl-1-substituted-5-(trifluoromethyl) pyrrole compounds useful as insecticidal, acaricidal and nematocidal agents and as intermediates for the manufacture of said agents AMERICAN CYANAMID COMPANY (US) 1992-09-01 US disclosed
US-5128485-A SYNTHESIS OF 2-ARYL-5-(TRIFLUOROMETHYL)PYRROLES USEFUL AS PESTICIDAL AGENTS AND AS INTERMEDIATES FOR THE PREPARATION OF SAID AGENTS AMERICAN CYANAMID COMPANY (US) 1992-07-07 US disclosed
EP-0492093-A2 Process for the preparation of 2-aryl 1-substituted-5-(trifluoromethyl)pyrrole compounds useful as insecticidal, acaricidal and nematocidal agents and as intermediates for the manufacture of said agents AMERICAN CYANAMID COMPANY (US) 1992-07-01 EP disclosed
EP-0491137-A2 Synthesis of 2-aryl-5-(trifluoromethyl)pyrroles useful as pesticidal agents and as intermediates for the preparation of said agents AMERICAN CYANAMID COMPANY (US) 1992-06-24 EP disclosed
US-5118816-A 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles AMERICAN CYANAMID COMPANY (US) 1992-06-02 US disclosed