Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.52 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL947723 | 0.85 | GPR119 (0.49) | HPGDSGPR119LMNAKMT2ATP53 | |
| SCHEMBL7547603 | 0.84 | POLB (0.48) | HPGDSGPR119MEN1KMT2APOLB | |
| SCHEMBL7545748 | 0.84 | GPR119 (0.45) | HPGDSGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL949286 | 0.84 | HPGDS (0.49) | HPGDSGPR119LMNAMEN1KMT2A | |
| SCHEMBL7546850 | 0.82 | GPR119 (0.43) | HPGDSGPR119LMNAMEN1KMT2A | |
| SCHEMBL19385367 | 0.79 | USP30 (0.57) | HPGDSUSP30GPR119CKS1BSKP1 | |
| SCHEMBL7551025 | 0.79 | GPR119 (0.47) | HPGDSGPR119LMNAMEN1KMT2A | |
| SCHEMBL22051946 | 0.78 | NAMPT (0.64) | HPGDSUSP30GPR119PTPN2PTPN1 | |
| SCHEMBL22050474 | 0.78 | NAMPT (0.64) | HPGDSUSP30GPR119PTPN2PTPN1 | |
| SCHEMBL949430 | 0.76 | GPR119 (0.50) | HPGDSGPR119LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171122-A4 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1171122-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| WO-2000059502-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |