SCHEMBL7544675

SCHEMBL7544675

CNC(C)COCc1cnccc1C

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36
CHRNB2 P17787 1/20 0.35
CHRNA4 P43681 1/20 0.35
AOC1 P19801 4/20 0.35
AOC3 Q16853 4/20 0.35
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
HDAC1 Q13547 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
HDAC5 Q9UQL6 1/20 0.33
SOST Q9BQB4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7547886 0.74 CHRNB2 (0.46) CHRNB2CHRNA4
SCHEMBL7545392 0.74 CHRNB2 (0.46) CHRNB2CHRNA4
SCHEMBL14348157 0.74 CYP11B1 (0.38) CYP11B1CYP11B2AOC1AOC3SLC6A2
SCHEMBL7548604 0.73 NPC1 (0.41) CHRNB2CHRNA4
SCHEMBL13838557 0.71 CYP11B1 (0.43) CYP11B1CYP11B2SLC6A2SLC6A4HDAC1
SCHEMBL7548586 0.68 MEN1 (0.38)
SCHEMBL18022521 0.68 CYP11B1 (0.41) CYP11B1CYP11B2AOC1AOC3SOST
SCHEMBL12462737 0.67 HDAC1 (0.40) CYP11B1CYP11B2SLC6A2SLC6A4HDAC1
SCHEMBL9138822 0.67
SCHEMBL21444695 0.65 TAAR1 (0.57)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212301-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-06-12 EP disclosed
WO-2001016107-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2001-03-08 WO disclosed