SCHEMBL7544987

SCHEMBL7544987

COC(=O)c1ccc2oc(COc3ccc(NC(C)=O)cc3)nc2c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.56
KMT2A Q03164 3/20 0.48
MEN1 O00255 2/20 0.48
ALDH1A1 P00352 2/20 0.47
HTT P42858 1/20 0.47
HSD17B10 Q99714 1/20 0.47
POLB P06746 3/20 0.47
GAA P10253 1/20 0.47
RAB9A P51151 5/20 0.47
NPC1 O15118 2/20 0.47
CASP3 P42574 2/20 0.47
SENP7 Q9BQF6 2/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
ALOX5AP P20292 1/20 0.45
FEN1 P39748 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
PDE10A Q9Y233 1/20 0.44
LMNA P02545 3/20 0.43
TDP1 Q9NUW8 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7545924 0.92 MAPT (0.47) MAPTALDH1A1RAB9ANPC1ALOX5AP
SCHEMBL7545090 0.92 MAPT (0.52) MAPTKMT2AMEN1ALDH1A1HTT
SCHEMBL7541702 0.86 MAPT (0.45) MAPTALDH1A1POLBGAARAB9A
SCHEMBL7541707 0.83 MAPT (0.52) MAPTALDH1A1POLBRAB9ANPC1
SCHEMBL7547340 0.82 MEN1 (0.60) MAPTKMT2AMEN1ALDH1A1HTT
SCHEMBL7547344 0.80 ALOX5AP (0.43) MAPTALDH1A1POLBRAB9ANPC1
SCHEMBL7550212 0.79 RAB9A (0.51) MAPTKMT2AALDH1A1POLBRAB9A
SCHEMBL7550243 0.79 MEN1 (0.51) MAPTKMT2AMEN1ALDH1A1HSD17B10
SCHEMBL7543368 0.78 AGPAT2 (0.57) MAPTKMT2AALDH1A1HSD17B10POLB
SCHEMBL3148127 0.78 HIF1A (0.54) KMT2AMEN1RAB9AALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0795550-B1 Aniline derivatives having herbicidal activity their preparation and their use SANKYO CO (JP) 2002-06-05 EP disclosed
US-5736487-A HERBICIDES SANKYO COMPANY, LIMITED (JP) 1998-04-07 US disclosed
EP-0795550-A1 Aniline derivatives having herbicidal activity their preparation and their use SANKYO COMPANY LIMITED (JP) 1997-09-17 EP disclosed