Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 8/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545020 | 1.00 | GRM2 (0.40) | GRM2ADAMTS4NAMPTLMNAHPGD | |
| SCHEMBL7545000 | 1.00 | GRM2 (0.40) | GRM2ADAMTS4NAMPTLMNAHPGD | |
| SCHEMBL7115876 | 0.91 | MMP2 (0.40) | GRM2ADAMTS4NAMPTLMNAHPGD | |
| SCHEMBL7115873 | 0.91 | MMP2 (0.40) | GRM2ADAMTS4NAMPTLMNAHPGD | |
| SCHEMBL7115880 | 0.91 | MMP2 (0.40) | GRM2ADAMTS4NAMPTLMNAHPGD | |
| SCHEMBL7123444 | 0.84 | GRM2 (0.33) | GRM2ADAMTS4NAMPTLMNASMN1; SMN2 | |
| SCHEMBL7122604 | 0.82 | SMN1; SMN2 (0.34) | GRM2ADAMTS4NAMPTLMNASMN1; SMN2 | |
| SCHEMBL7123675 | 0.79 | MMP2 (0.44) | ADAMTS4NAMPTMMP9MMP2 | |
| SCHEMBL7123678 | 0.79 | MMP2 (0.44) | ADAMTS4NAMPTMMP9MMP2 | |
| SCHEMBL7545570 | 0.76 | SIGMAR1 (0.35) | MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265855-A1 | NOVEL CD23 INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001062715-A1 | NOVEL CD23 INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-30 | — | — | WO | disclosed |