Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.33 |
| ▸ | WNT3A | P56704 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | PER2 | O15055 | 1/20 | 0.31 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.31 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7122205 | 0.94 | MMP13 (0.40) | SIGMAR1MMP2MMP13CTNNB1WNT3A | |
| SCHEMBL7126419 | 0.91 | MMP13 (0.42) | SIGMAR1MMP2MMP13CTNNB1WNT3A | |
| SCHEMBL7126425 | 0.91 | MMP13 (0.42) | SIGMAR1MMP2MMP13CTNNB1WNT3A | |
| SCHEMBL7122194 | 0.84 | MMP2 (0.30) | MMP2MMP13 | |
| SCHEMBL7116976 | 0.83 | MMP2 (0.30) | MMP2MMP13 | |
| SCHEMBL7116990 | 0.79 | L3MBTL1 (0.37) | SIGMAR1MMP2MMP13L3MBTL1 | |
| SCHEMBL7156200 | 0.78 | SIGMAR1 (0.34) | SIGMAR1MMP2MMP13CA12CA2 | |
| SCHEMBL7123700 | 0.78 | MMP13 (0.41) | MMP2MMP13CTNNB1WNT3ACA12 | |
| SCHEMBL7123706 | 0.78 | MMP13 (0.41) | MMP2MMP13CTNNB1WNT3ACA12 | |
| SCHEMBL7123704 | 0.78 | MMP13 (0.41) | MMP2MMP13CTNNB1WNT3ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265855-A1 | NOVEL CD23 INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001062715-A1 | NOVEL CD23 INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-30 | — | — | WO | disclosed |