Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5451636 | 0.82 | NPC1 (0.67) | RENNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2902849 | 0.81 | NPC1 (0.62) | RENNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7545892 | 0.81 | REN (0.56) | RENNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL27498819 | 0.80 | NPC1 (0.60) | RENNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL17532686 | 0.80 | ALDH1A1 (0.46) | RENNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2798062 | 0.78 | REN (0.61) | RENNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11125181 | 0.78 | ALDH1A1 (0.50) | NPC1RAB9AKMT2AMEN1TDP1 | |
| SCHEMBL29550302 | 0.76 | ALDH1A1 (0.48) | NPC1RAB9AKMT2AMEN1TDP1 | |
| SCHEMBL17061628 | 0.76 | VNN1 (0.58) | RENNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL17061616 | 0.76 | VNN1 (0.58) | RENNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815091-B1 | POLYAZACYCLOALKANE COMPOUNDS | NYCOMED IMAGING AS (NO) | 2002-06-12 | — | — | EP | disclosed |
| EP-0815091-A1 | POLYAZACYCLOALKANE COMPOUNDS | NYCOMED IMAGING AS (NO) | 1998-01-07 | — | — | EP | disclosed |
| US-5705637-A | Polyazacycloalkane compounds | NYCOMED IMAGING AS (NO) | 1998-01-06 | — | — | US | disclosed |
| US-5677446-A | Polyazacycloalkane compounds | NYCOMED IMAGING AS (NO) | 1997-10-14 | — | — | US | disclosed |
| US-5631368-A | Polyazacycloalkane compounds | NYCOMED IMAGING AS (NO) | 1997-05-20 | — | — | US | disclosed |
| WO-1996028433-A1 | POLYAZACYCLOALKANE COMPOUNDS | NYCOMED IMAGING A.S (NO) | 1996-09-19 | — | — | WO | disclosed |