Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | EPOR | P19235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545910 | 1.00 | ALDH1A1 (0.41) | ALDH1A1TSHRNPC1MAPTMAPK1 | |
| SCHEMBL7546223 | 0.82 | CHRNB2 (0.54) | ALDH1A1TSHRNPC1MAPTMAPK1 | |
| SCHEMBL7546225 | 0.82 | CHRNB2 (0.54) | ALDH1A1TSHRNPC1MAPTMAPK1 | |
| SCHEMBL13703007 | 0.78 | HTR2A (0.42) | ALDH1A1TSHRMAPTHTR2AHDAC4 | |
| SCHEMBL6258001 | 0.78 | CYP19A1 (0.50) | NPC1MAPTHTR2A | |
| SCHEMBL6258006 | 0.78 | CYP19A1 (0.50) | NPC1MAPTHTR2A | |
| SCHEMBL13703006 | 0.78 | HTR2A (0.42) | ALDH1A1TSHRMAPTHTR2AHDAC4 | |
| SCHEMBL13703292 | 0.76 | HDAC4 (0.41) | ALDH1A1HTR2AHDAC4MEF2DEPOR | |
| SCHEMBL13703318 | 0.76 | HDAC4 (0.41) | ALDH1A1HTR2AHDAC4MEF2DEPOR | |
| SCHEMBL5475692 | 0.76 | HTR2A (0.66) | TSHRHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| US-6337351-B1 | AROMATIC OLEFIN AMINES | TARGACEPT, INC. | 2002-01-08 | — | — | US | disclosed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | disclosed |