Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6761509 | 0.84 | HPGD (0.40) | SMN1; SMN2RAB9ANPC1TAS1R3TAS1R1 | |
| SCHEMBL4427904 | 0.84 | POLB (0.42) | TAS1R3TAS1R1HPGDGAA | |
| SCHEMBL4426829 | 0.83 | POLB (0.42) | TAS1R3TAS1R1HPGDGAA | |
| SCHEMBL4428468 | 0.79 | POLB (0.43) | RAB9ANPC1TAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL4431181 | 0.71 | POLB (0.40) | KMT2AALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL1486246 | 0.66 | TAS1R3 (0.65) | SMN1; SMN2RAB9ANPC1TAS1R3TAS1R1 | |
| SCHEMBL4201407 | 0.66 | TAS1R3 (1.00) | SMN1; SMN2RAB9ANPC1TAS1R3TAS1R1 | |
| SCHEMBL14255869 | 0.63 | TAS1R3 (0.60) | SMN1; SMN2RAB9ANPC1TAS1R3TAS1R1 | |
| SCHEMBL13144657 | 0.63 | HPGD (0.46) | SMN1; SMN2RAB9ANPC1TP53ALDH1A1 | |
| SCHEMBL12829017 | 0.63 | LMNA (0.65) | SMN1; SMN2RAB9ANPC1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189881-A4 | PROPANOIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | TEXAS BIOTECHNOLOGY CORP (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1189881-A1 | PROPANOIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000068188-A1 | PROPANOIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2000-11-16 | — | — | WO | disclosed |