Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 11/20 | 0.43 |
| ▸ | TP53 | P04637 | 7/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5267998 | 0.86 | LMNA (0.54) | CA2MAPTTP53THRBUSP2 | |
| SCHEMBL6596793 | 0.83 | LMNA (0.41) | CA2MAPTTP53THRBUSP2 | |
| SCHEMBL7495653 | 0.83 | KEAP1 (0.54) | CA2MAPTHSP90AB1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5267650 | 0.81 | CSNK2A1 (0.47) | CA2MAPTTP53THRBUSP2 | |
| SCHEMBL6598255 | 0.81 | MAPT (0.46) | CA2MAPTTP53THRBUSP2 | |
| SCHEMBL20893351 | 0.81 | MAPT (0.48) | CA2MAPTTP53POLBALDH1A1 | |
| SCHEMBL7540393 | 0.78 | HDAC3 (0.57) | MAPTTP53POLBALDH1A1LMNA | |
| SCHEMBL25464445 | 0.77 | CA2 (0.47) | CA2MAPTTP53THRBUSP2 | |
| SCHEMBL14395851 | 0.76 | MAPT (0.42) | CA2MAPTTP53THRBUSP2 | |
| SCHEMBL11258847 | 0.74 | MAPT (0.50) | CA2MAPTTP53THRBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187836-A1 | SUBSTITUTED IMIDAZOTHIAZOLES AS ANTIDEPRESSANT AGENTS | Knoll GmbH (DE) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000071548-A1 | SUBSTITUTED IMIDAZOTHIAZOLES AS ANTIDEPRESSANT AGENTS | KNOLL GMBH (DE) | 2000-11-30 | — | — | WO | disclosed |