Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.75 |
| ▸ | ACHE | P22303 | 6/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9986661 | 0.93 | CCR2 (0.75) | CCR2ACHESIGMAR1TP53CYP1A2 | |
| SCHEMBL22853299 | 0.86 | CCR2 (0.76) | CCR2ACHESIGMAR1TP53CYP1A2 | |
| SCHEMBL7153825 | 0.86 | CCR2 (1.00) | CCR2ACHESIGMAR1TP53CYP1A2 | |
| SCHEMBL7546720 | 0.85 | CCR2 (0.79) | CCR2ACHECHRM1HTR2AMCHR1 | |
| SCHEMBL7546974 | 0.81 | CCR2 (0.76) | CCR2ACHE | |
| SCHEMBL7159464 | 0.81 | CCR2 (0.85) | CCR2ACHECYP1A2CYP2D6CYP3A4 | |
| SCHEMBL7547201 | 0.80 | CCR2 (0.47) | CCR2ACHESIGMAR1 | |
| SCHEMBL7550045 | 0.79 | CCR2 (0.79) | CCR2ACHETP53TSHRCYP3A4 | |
| SCHEMBL7549399 | 0.79 | CCR2 (0.79) | CCR2ACHETSHR | |
| SCHEMBL7553543 | 0.79 | CCR2 (0.79) | CCR2ACHESIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020099054-A1 | 2-phenyl benzimidazole derivatives as MCP-1 antagonists | WARNER-LAMBERT COMPANY (US) | 2002-07-25 | — | — | US | claimed |
| US-6184235-B1 | MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) ANTAGONIST FOR TREATMENT OF INFLAMMATORY DISEASES, ATHEROSCLEROSIS, RESTENOSIS, AUTOIMMUNE DISEASES, ORGAN TRANSPLANT REJECTION IN MAMMALS | WARNER-LAMBERT COMPANY | 2001-02-06 | — | — | US | claimed |
| EP-0927167-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-07-07 | — | — | EP | claimed |
| WO-1998006703-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-02-19 | — | — | WO | claimed |
| US-12016935-B2 | Methods for detecting CCR2 receptors | WASHINGTON UNIVERSITY (US) | 2024-06-25 | — | — | US | disclosed |
| US-12016935-B2 | Methods for detecting CCR2 receptors | WASHINGTON UNIVERSITY (US) | 2024-06-25 | — | — | US | disclosed |
| US-20180085445-A1 | OPTIMIZED CANCER STEM CELL VACCINES | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION | 2018-03-29 | — | — | US | disclosed |
| US-20180085445-A1 | OPTIMIZED CANCER STEM CELL VACCINES | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION | 2018-03-29 | — | — | US | disclosed |
| US-20170348442-A1 | COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS | WASHINGTON UNIVERSITY (US) | 2017-12-07 | — | — | US | disclosed |
| US-20170348442-A1 | COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS | WASHINGTON UNIVERSITY (US) | 2017-12-07 | — | — | US | disclosed |
| US-20160287686-A1 | MYELOID DERIVED SUPPRESSOR CELL INHIBITING AGENTS | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION | 2016-10-06 | — | — | US | disclosed |
| US-20160287686-A1 | MYELOID DERIVED SUPPRESSOR CELL INHIBITING AGENTS | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION | 2016-10-06 | — | — | US | disclosed |
| US-9320735-B2 | Myeloid derived suppressor cell inhibiting agents | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2016-04-26 | — | — | US | disclosed |
| US-9320735-B2 | Myeloid derived suppressor cell inhibiting agents | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2016-04-26 | — | — | US | disclosed |
| US-20120156280-A1 | MYELOID DERIVED SUPPRESSOR CELL INHIBITING AGENTS | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120156280-A1 | MYELOID DERIVED SUPPRESSOR CELL INHIBITING AGENTS | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160287686-A1 | MYELOID DERIVED SUPPRESSOR CELL INHIBITING AGENTS | CCR2, CSF3R, CSF1R | CCR2 1/4885ACHE 4744/4885SIGMAR1 2958/4885 |
| US-20120156280-A1 | MYELOID DERIVED SUPPRESSOR CELL INHIBITING AGENTS | CCR2, CSF3R, CSF1R | CCR2 1/4885ACHE 4744/4885SIGMAR1 2958/4885 |
| US-20020099054-A1 | 2-phenyl benzimidazole derivatives as MCP-1 antagonists | CCR1, CCR2, CCR8 | CCR2 2/4885ACHE 4652/4885SIGMAR1 66/4885 |
| US-20170348442-A1 | COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS | CCR2, CCR1, CCR3 | CCR2 1/4885ACHE 4812/4885SIGMAR1 397/4885 |
| US-12016935-B2 | Methods for detecting CCR2 receptors | CCR2, CCR1, CCR5 | CCR2 1/4885ACHE 4825/4885SIGMAR1 345/4885 |
| US-20180085445-A1 | OPTIMIZED CANCER STEM CELL VACCINES | CD44, TP53, TSG101 | CCR2 1229/4885ACHE 4178/4885SIGMAR1 4691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.