Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1593533 | 0.81 | MAPK1 (0.42) | MAPK1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL7547268 | 0.78 | MAPK1 (0.39) | MAPK1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL1594422 | 0.71 | NPY5R (0.44) | KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL7498739 | 0.70 | ALDH1A1 (0.33) | KMT2AALDH1A1CA1CA2CA9 | |
| SCHEMBL1593535 | 0.65 | MAPK1 (0.47) | MAPK1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL7503785 | 0.61 | L3MBTL1 (0.36) | KMT2AMEN1LMNACA1CA2 | |
| SCHEMBL11564141 | 0.57 | MAPK1 (0.54) | MAPK1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL16131109 | 0.56 | TSHR (0.57) | MAPK1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL31086535 | 0.56 | LMNA (0.62) | KMT2AMEN1LMNAALDH1A1HTT | |
| SCHEMBL31086505 | 0.56 | LMNA (0.62) | KMT2AMEN1LMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183245-A4 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2002-10-02 | — | — | EP | disclosed |
| EP-1183245-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000064880-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-11-02 | — | — | WO | disclosed |