Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PELI1 | Q96FA3 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.44 |
| ▸ | TYR | P14679 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617301 | 0.81 | CHRNA7 (0.64) | PELI1CHRNA7TYRBACE1 | |
| SCHEMBL617300 | 0.81 | CHRNA7 (0.64) | PELI1CHRNA7TYRBACE1 | |
| SCHEMBL5595108 | 0.80 | PELI1 (0.47) | PELI1CHRNA7TYRBACE1CCNC | |
| SCHEMBL27516296 | 0.80 | PELI1 (0.47) | PELI1CHRNA7TYRBACE1CCNC | |
| SCHEMBL517599 | 0.79 | PELI1 (0.46) | PELI1CHRNA7TYR | |
| SCHEMBL765999 | 0.73 | NFKB1 (0.70) | CHRNA7NFKB1JUNNFE2L2CA1 | |
| SCHEMBL29625452 | 0.73 | NFKB1 (0.70) | CHRNA7NFKB1JUNNFE2L2CA1 | |
| SCHEMBL1608290 | 0.73 | NFKB1 (0.70) | CHRNA7NFKB1JUNNFE2L2CA1 | |
| SCHEMBL8687395 | 0.73 | NFKB1 (0.70) | CHRNA7NFKB1JUNNFE2L2CA1 | |
| SCHEMBL766000 | 0.73 | NFKB1 (0.70) | CHRNA7NFKB1JUNNFE2L2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |