Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.58 |
| ▸ | FLT1 | P17948 | 4/20 | 0.58 |
| ▸ | FLT4 | P35916 | 4/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | GAK | O14976 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550794 | 0.92 | KDR (0.56) | KDRFLT1FLT4CYP2A6TDP2 | |
| SCHEMBL7976277 | 0.88 | KDR (0.43) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7551876 | 0.87 | KDR (0.72) | KDRFLT1FLT4CYP2A6NFATC1 | |
| SCHEMBL7557902 | 0.86 | KDR (0.46) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7988607 | 0.85 | KDR (0.43) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7988018 | 0.85 | KDR (0.78) | KDRFLT1FLT4CYP2A6TDP2 | |
| SCHEMBL7990418 | 0.83 | KDR (0.39) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7553622 | 0.82 | KDR (0.55) | KDRFLT1FLT4CYP2A6TDP2 | |
| SCHEMBL7991178 | 0.81 | KDR (0.54) | KDRFLT1FLT4CYP2A6 | |
| SCHEMBL7976429 | 0.79 | KDR (0.78) | KDRFLT1FLT4CYP2A6TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| US-6281389-B1 | MIXING WITH SOLVENT; DISTILLATION | NIPPON SHOKUBAI CO., LTD. (JP) | 2001-08-28 | — | — | US | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |