Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.34 |
| ▸ | PGR | P06401 | 3/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557902 | 0.94 | KDR (0.46) | KDRFLT1FLT4DYRK1ANFATC1 | |
| SCHEMBL7990418 | 0.92 | KDR (0.39) | KDRFLT1FLT4MAP4K4ALPL | |
| SCHEMBL7988607 | 0.91 | KDR (0.43) | KDRFLT1FLT4DYRK1ANFATC1 | |
| SCHEMBL7552885 | 0.90 | KDR (0.51) | KDRFLT1FLT4DYRK1ANFATC1 | |
| SCHEMBL7547648 | 0.88 | KDR (0.58) | KDRFLT1FLT4DYRK1ANFATC1 | |
| SCHEMBL7548512 | 0.85 | KDR (0.43) | KDRFLT1FLT4SLC2A1 | |
| SCHEMBL7987876 | 0.84 | PDE4B (0.45) | KDRFLT1FLT4ALPLCYP11B1 | |
| SCHEMBL7548685 | 0.83 | KDR (0.60) | KDRFLT1FLT4DYRK1AMAP4K4 | |
| SCHEMBL7986476 | 0.82 | KDR (0.39) | KDRFLT1FLT4MAP4K4CHRNB1 | |
| SCHEMBL7994139 | 0.82 | KDR (0.41) | KDRFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |