Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | BMP4 | P12644 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976277 | 0.92 | KDR (0.43) | KDRFLT1FLT4ALPLMAP4K4 | |
| SCHEMBL7987876 | 0.89 | PDE4B (0.45) | KDRFLT1FLT4ALPLPDE4B | |
| SCHEMBL7557902 | 0.88 | KDR (0.46) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7550587 | 0.87 | KDR (0.49) | KDRFLT1FLT4BMP4MAP4K4 | |
| SCHEMBL7549809 | 0.86 | HTR6 (0.43) | KDRFLT1FLT4ALPLMAP4K4 | |
| SCHEMBL7988607 | 0.85 | KDR (0.43) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7552885 | 0.83 | KDR (0.51) | KDRFLT1FLT4MAP4K4PDE4B | |
| SCHEMBL7547648 | 0.83 | KDR (0.58) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7976435 | 0.82 | PRKCA (0.42) | KDRFLT1FLT4ALPLPDE4B | |
| SCHEMBL7990227 | 0.82 | PDE4B (0.45) | KDRFLT1FLT4PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |