SCHEMBL7548411

SCHEMBL7548411

NC[CH]CCOCc1cccnc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.46
CYP2A6 P11509 3/20 0.44
CHRNB2 P17787 3/20 0.42
CHRNA4 P43681 3/20 0.42
CHRM2 P08172 2/20 0.42
CHRM1 P11229 2/20 0.42
CHRM3 P20309 2/20 0.42
HRH1 P35367 2/20 0.41
MGMT P16455 1/20 0.40
CYP2D6 P10635 3/20 0.40
CYP1A2 P05177 2/20 0.40
HSD11B1 P28845 1/20 0.39
CYP2E1 P05181 2/20 0.39
CYP3A4 P08684 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2B6 P20813 2/20 0.39
CYP2C19 P33261 2/20 0.39
HTR1A P08908 1/20 0.38
DRD2 P14416 1/20 0.38
CYP2C8 P10632 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2565875 0.82 CHRNA7 (0.58) CHRNA7CYP2A6CHRNB2CHRNA4CHRM2
SCHEMBL17713225 0.79 CHRNA7 (0.55) CHRNA7CYP2A6CHRNB2CHRNA4CHRM2
SCHEMBL7552891 0.79 CYP2A6 (0.61) CHRNA7CYP2A6CHRNB2CHRNA4CHRM2
SCHEMBL493020 0.77 CYP1A2 (0.56) CHRNA7CYP2A6CHRNB2CHRNA4CHRM2
Hydrochloric Acid SCHEMBL27794086 0.75 CYP1A2 (0.54) CHRNA7CYP2A6CHRNB2CHRNA4CHRM2
SCHEMBL10263928 0.75 TDP1 (0.53) CHRNA7CHRNB2CHRNA4CHRM2CHRM1
SCHEMBL29469530 0.75 HSD11B1 (0.47) CHRNA7CYP2A6CHRNB2CHRNA4CHRM2
SCHEMBL8200733 0.75 CHRNB2 (0.47) CHRNA7CYP2A6CHRNB2CHRNA4CHRM2
SCHEMBL149174 0.75 HSD11B1 (0.47) CHRNA7CYP2A6CHRNB2CHRNA4CHRM2
SCHEMBL146442 0.75 HSD11B1 (0.47) CHRNA7CYP2A6CHRNB2CHRNA4CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212301-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-06-12 EP disclosed
WO-2001016107-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2001-03-08 WO disclosed