Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 13/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.41 |
| ▸ | USP2 | O75604 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 7/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.36 |
| ▸ | DRD3 | P35462 | 5/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550218 | 0.87 | ALDH1A1 (0.42) | HSD17B10ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL7159220 | 0.87 | CYP1A2 (0.44) | HSD17B10ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL7660693 | 0.84 | HSD17B10 (0.40) | HSD17B10ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL7157946 | 0.81 | KDM4E (0.48) | HSD17B10ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL7159607 | 0.80 | NPC1 (0.80) | HSD17B10ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL7155344 | 0.80 | CYP1A2 (0.40) | HSD17B10ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL7154096 | 0.78 | NPC1 (0.65) | HSD17B10ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL7155256 | 0.76 | ALDH1A1 (0.63) | HSD17B10ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL7551302 | 0.75 | CYP1A2 (0.39) | HSD17B10ALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL9611672 | 0.74 | CYP1A2 (0.65) | HSD17B10ALDH1A1HPGDLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020099054-A1 | 2-phenyl benzimidazole derivatives as MCP-1 antagonists | WARNER-LAMBERT COMPANY (US) | 2002-07-25 | — | — | US | disclosed |
| US-6348487-B1 | ANTIINFLAMMATORY AGENTS, ATHEROSCLEROSIS, RESTINOSIS AND IMMUNE DISORDERS | MILLENNIUM PHARMACEUTICALS, INC. | 2002-02-19 | — | — | US | disclosed |
| US-6184235-B1 | MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) ANTAGONIST FOR TREATMENT OF INFLAMMATORY DISEASES, ATHEROSCLEROSIS, RESTENOSIS, AUTOIMMUNE DISEASES, ORGAN TRANSPLANT REJECTION IN MAMMALS | WARNER-LAMBERT COMPANY | 2001-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099054-A1 | 2-phenyl benzimidazole derivatives as MCP-1 antagonists | CCR1, CCR2, CCR8 | HSD17B10 3382/4885ALDH1A1 2817/4885HPGD 3609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.