Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.34 |
| ▸ | USP2 | O75604 | 6/20 | 0.34 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | DRD3 | P35462 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159199 | 0.88 | CYP1A2 (0.37) | HSD17B10ALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL7548704 | 0.84 | HSD17B10 (0.51) | HSD17B10ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7155292 | 0.84 | MYC (0.39) | HSD17B10ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7550218 | 0.84 | ALDH1A1 (0.42) | HSD17B10ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7156031 | 0.83 | MAPT (0.58) | HSD17B10ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7152128 | 0.81 | CYP1A2 (0.36) | HSD17B10ALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL7160902 | 0.81 | ALDH1A1 (0.49) | HSD17B10ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7160138 | 0.79 | ALDH1A1 (0.46) | HSD17B10ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8520141 | 0.78 | NPC1 (0.67) | HSD17B10ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7159519 | 0.74 | KMT2A (0.40) | HSD17B10ALDH1A1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6348487-B1 | ANTIINFLAMMATORY AGENTS, ATHEROSCLEROSIS, RESTINOSIS AND IMMUNE DISORDERS | MILLENNIUM PHARMACEUTICALS, INC. | 2002-02-19 | — | — | US | disclosed |
| US-6184235-B1 | MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) ANTAGONIST FOR TREATMENT OF INFLAMMATORY DISEASES, ATHEROSCLEROSIS, RESTENOSIS, AUTOIMMUNE DISEASES, ORGAN TRANSPLANT REJECTION IN MAMMALS | WARNER-LAMBERT COMPANY | 2001-02-06 | — | — | US | disclosed |