Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.30 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547397 | 0.96 | CNR1 (0.32) | KDM4EMAPTNR1I3ALDH1A1 | |
| SCHEMBL7555176 | 0.88 | KDM4E (0.31) | ALOX15KDM4EMAPTHSD17B10LMNA | |
| SCHEMBL7550091 | 0.88 | NR1I3 (0.32) | NR1I3 | |
| SCHEMBL7549047 | 0.86 | MAPK14 (0.33) | KDM4EHPGDNR1I3ALDH1A1 | |
| SCHEMBL7547271 | 0.86 | RORC (0.31) | NR1I3 | |
| SCHEMBL7548644 | 0.85 | MAPK14 (0.32) | KDM4EHPGDNR1I3ALDH1A1 | |
| SCHEMBL7550465 | 0.85 | MAPK14 (0.31) | NR1I3 | |
| SCHEMBL7551089 | 0.82 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL7548912 | 0.79 | NR1I3 (0.31) | NR1I3 | |
| SCHEMBL7549035 | 0.79 | MTNR1A (0.36) | KDM4EMAPTHSD17B10LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |