Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.30 |
| ▸ | NPY1R | P25929 | 1/20 | 0.30 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547271 | 0.94 | RORC (0.31) | MAPK14NR1I3RAF1SIRT2SIRT1 | |
| SCHEMBL7548912 | 0.94 | NR1I3 (0.31) | NR1I3NPY1RSIRT2SIRT1RORC | |
| SCHEMBL7548644 | 0.90 | MAPK14 (0.32) | MAPK14NR1I3NPY1RRAF1SIRT2 | |
| SCHEMBL7549047 | 0.89 | MAPK14 (0.33) | MAPK14NR1I3RAF1SIRT2SIRT1 | |
| SCHEMBL7547397 | 0.87 | CNR1 (0.32) | MAPK14NR1I3RAF1SIRT2SIRT1 | |
| SCHEMBL7555176 | 0.87 | KDM4E (0.31) | — | |
| SCHEMBL7548911 | 0.85 | AAK1 (0.33) | — | |
| SCHEMBL7549039 | 0.85 | ALOX15 (0.32) | NR1I3 | |
| SCHEMBL7550091 | 0.84 | NR1I3 (0.32) | NR1I3NPY1RSIRT2SIRT1RORC | |
| SCHEMBL7551128 | 0.82 | AAK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |