Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926059 | 0.89 | PTGS1 (0.67) | PTGS1PTGS2HDAC1HDAC6KDM4E | |
| SCHEMBL6923513 | 0.81 | HDAC1 (0.76) | PTGS1PTGS2HDAC1HDAC6LMNA | |
| SCHEMBL6925477 | 0.79 | PTGS1 (0.65) | PTGS1PTGS2HDAC1HDAC6KDM4E | |
| SCHEMBL2301312 | 0.78 | LMNA (0.60) | KDM4ELMNAGAAALDH1A1HPGD | |
| SCHEMBL6920465 | 0.77 | HDAC1 (0.64) | PTGS1PTGS2HDAC1HDAC6KDM4E | |
| SCHEMBL6921299 | 0.74 | HDAC1 (0.69) | PTGS1PTGS2HDAC1HDAC6MAPT | |
| SCHEMBL6921570 | 0.73 | DYRK1A (0.46) | KDM4ELMNAGAAALDH1A1HPGD | |
| SCHEMBL5794392 | 0.73 | ALDH1A1 (0.66) | PTGS1PTGS2HDAC1HDAC6KDM4E | |
| SCHEMBL14894319 | 0.72 | HDAC1 (0.79) | PTGS1PTGS2HDAC1HDAC6KDM4E | |
| SCHEMBL7115322 | 0.71 | LMNA (0.51) | KDM4ELMNAGAAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |