Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 8/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990350 | 0.93 | KDR (0.55) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7976879 | 0.92 | KDR (0.50) | KDRFLT1FLT4CNR2MKNK2 | |
| SCHEMBL7990572 | 0.92 | KDR (0.50) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7549676 | 0.92 | KDR (0.50) | KDRFLT1FLT4CNR2LMNA | |
| SCHEMBL7990490 | 0.87 | KDR (0.49) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7987725 | 0.86 | KDR (0.70) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7554297 | 0.86 | KDR (0.54) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7549404 | 0.86 | KDR (0.51) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7553359 | 0.86 | CNR2 (0.42) | KDRFLT1FLT4CNR2MKNK2 | |
| SCHEMBL7990662 | 0.86 | KDR (0.68) | KDRFLT1FLT4CNR2MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |