Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 8/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 4/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549297 | 0.84 | MAPK8 (0.36) | MAPK8MAPK9MAPK10HTR6HSD17B10 | |
| SCHEMBL7549335 | 0.80 | MAPK8 (0.35) | MAPK8MAPK9MAPK10PPARAPPARG | |
| SCHEMBL7550102 | 0.78 | NLRP3 (0.37) | PPARDMAPK8MAPK9MAPK10PPARA | |
| SCHEMBL7551106 | 0.77 | NAMPT (0.31) | MAPK8 | |
| SCHEMBL7550297 | 0.69 | GRIN1 (0.41) | PPARDPPARAHSD17B10 | |
| SCHEMBL8874979 | 0.66 | NOD2 (0.49) | NOD2NOD1MEN1KMT2A | |
| SCHEMBL8346527 | 0.64 | NOD2 (0.47) | NOD2NOD1MEN1KMT2A | |
| SCHEMBL8971346 | 0.63 | ACLY (0.47) | PPARDPPARAPPARGMEN1KMT2A | |
| SCHEMBL2000226 | 0.62 | KMT2A (0.40) | PPARDPTGDRPPARAPPARGNOD2 | |
| SCHEMBL22003908 | 0.61 | ACLY (0.78) | PTGDRMAPK8MAPK9MAPK10HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |