Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.81 |
| ▸ | FLT1 | P17948 | 4/20 | 0.69 |
| ▸ | FLT4 | P35916 | 4/20 | 0.69 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550287 | 0.90 | KDR (1.00) | KDRFLT1FLT4CYP2A6HTR1D | |
| SCHEMBL7554970 | 0.88 | KDR (0.81) | KDRFLT1FLT4CYP2A6CAMK2D | |
| SCHEMBL7553991 | 0.86 | KDR (1.00) | KDRFLT1FLT4CYP2A6KCNH2 | |
| SCHEMBL7551626 | 0.84 | KDR (0.79) | KDRFLT1FLT4CYP2A6CAMK2D | |
| SCHEMBL7550368 | 0.83 | KDR (0.73) | KDRFLT1FLT4CYP2A6CAMK2D | |
| SCHEMBL7547755 | 0.82 | KDR (1.00) | KDRFLT1FLT4CYP2A6DYRK1A | |
| SCHEMBL7555190 | 0.80 | KDR (1.00) | KDRFLT1FLT4CYP2A6DYRK1A | |
| SCHEMBL7976107 | 0.80 | KDR (0.68) | KDRFLT1FLT4CYP2A6CAMK2D | |
| SCHEMBL7556531 | 0.80 | KDR (1.00) | KDRFLT1FLT4CYP2A6DYRK1A | |
| SCHEMBL7549908 | 0.80 | KDR (1.00) | KDRFLT1FLT4CYP2A6DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |