Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.68 |
| ▸ | FLT1 | P17948 | 4/20 | 0.57 |
| ▸ | FLT4 | P35916 | 4/20 | 0.57 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 2/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550368 | 0.90 | KDR (0.73) | KDRFLT1FLT4DYRK1ACYP2A6 | |
| SCHEMBL7551626 | 0.86 | KDR (0.79) | KDRFLT1FLT4GSK3BDYRK1A | |
| SCHEMBL7554970 | 0.84 | KDR (0.81) | KDRFLT1FLT4GSK3BDYRK1A | |
| SCHEMBL7550287 | 0.82 | KDR (1.00) | KDRFLT1FLT4GSK3BCYP2A6 | |
| SCHEMBL7549872 | 0.80 | KDR (0.81) | KDRFLT1FLT4GSK3BDYRK1A | |
| SCHEMBL7553991 | 0.78 | KDR (1.00) | KDRFLT1FLT4GSK3BCYP2A6 | |
| SCHEMBL7555190 | 0.73 | KDR (1.00) | KDRFLT1FLT4GSK3BDYRK1A | |
| SCHEMBL7556531 | 0.72 | KDR (1.00) | KDRFLT1FLT4GSK3BDYRK1A | |
| SCHEMBL7549908 | 0.72 | KDR (1.00) | KDRFLT1FLT4GSK3BDYRK1A | |
| SCHEMBL7506453 | 0.72 | KDR (1.00) | KDRFLT1FLT4GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |