Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 3/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549280 | 0.84 | PDE3B (0.46) | MAPTTYMSBACE1CASP3TUBB4A | |
| SCHEMBL7550534 | 0.83 | PDE3B (0.44) | CHEK1MAPTNPSR1RXFP1TYMS | |
| SCHEMBL7547477 | 0.81 | KDM4E (0.44) | CHEK1PIM3GAAMAPTNPSR1 | |
| SCHEMBL7549332 | 0.78 | CSNK2A1 (0.33) | PDE3BPDE3A | |
| SCHEMBL7545063 | 0.78 | CSNK2A1 (0.35) | — | |
| SCHEMBL26732566 | 0.73 | PRMT5 (0.46) | CHEK1PIM1AKT1FLT3PIM3 | |
| SCHEMBL7508327 | 0.70 | PRMT5 (0.32) | GAAMAPTNPSR1RXFP1PRMT5 | |
| SCHEMBL6920515 | 0.66 | CSNK2A1 (0.38) | CHEK1PIM1AKT1FLT3PIM3 | |
| SCHEMBL29768297 | 0.64 | BACE1 (0.58) | MAPTBACE1ALDH1A1KDM4EMEN1 | |
| SCHEMBL4347785 | 0.64 | BACE1 (0.58) | MAPTBACE1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931081-B1 | PYRIDAZINO 4,5-B]-QUINOLINE 5-OXIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS GLYCINE ANTAGONISTS | MERZ & CO GMBH & CO (DE) | 2002-09-25 | — | — | EP | claimed |