Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549280 | 0.82 | PDE3B (0.46) | KDM4EMAPTPDE3BPDE3ACYP1A2 | |
| SCHEMBL7550176 | 0.81 | CHEK1 (0.38) | KDM4ERXFP1MAPTGAAKMT2A | |
| SCHEMBL7550534 | 0.81 | PDE3B (0.44) | KDM4ERXFP1MAPTKMT2ALMNA | |
| SCHEMBL7549769 | 0.77 | NQO2 (0.34) | KDM4EMAPTGAALMNAPDE3B | |
| SCHEMBL9686737 | 0.76 | GAA (0.63) | KDM4ERXFP1MAPTGAAKMT2A | |
| SCHEMBL8450332 | 0.75 | KDM4E (0.46) | KDM4ERXFP1MAPTGAAKMT2A | |
| SCHEMBL7545063 | 0.73 | CSNK2A1 (0.35) | GSK3BCSNK2A1CYP1A2 | |
| SCHEMBL765469 | 0.70 | ATM (0.57) | KDM4EMAPTGAAKMT2ALMNA | |
| SCHEMBL633820 | 0.70 | PARP1 (0.53) | KDM4EKMT2ALMNAPDE2APDE3B | |
| SCHEMBL7546810 | 0.70 | KDM4E (0.42) | KDM4ERXFP1MAPTGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931081-B1 | PYRIDAZINO 4,5-B]-QUINOLINE 5-OXIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS GLYCINE ANTAGONISTS | MERZ & CO GMBH & CO (DE) | 2002-09-25 | — | — | EP | claimed |