Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | FER | P16591 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6917710 | 0.88 | PDPK1 (0.37) | CSNK2A1PDPK1JAK2FLT3DCLK1 | |
| SCHEMBL6921370 | 0.78 | JAK2 (0.41) | JAK2CHEK1PIM1PRKD3MAP4K4 | |
| SCHEMBL6918858 | 0.77 | GPR3 (0.45) | FLT3CHEK1LMNAMAP4K4CSF1R | |
| SCHEMBL30896407 | 0.77 | GPR3 (0.45) | FLT3CHEK1LMNAMAP4K4CSF1R | |
| SCHEMBL6919545 | 0.74 | NMT2 (0.49) | PIM1MAPTLMNAMAP4K4CDK2 | |
| SCHEMBL6914017 | 0.74 | MAP4K4 (0.42) | PDPK1CHEK1PIM1PIM3MAP4K4 | |
| SCHEMBL6917877 | 0.73 | ERN1 (0.40) | CHEK1CDK2GABRA1GABRG2GABRB3 | |
| SCHEMBL6661870 | 0.71 | NISCH (0.33) | PDPK1FLT3CHEK1MAPTHTT | |
| SCHEMBL11518864 | 0.71 | PABPC1 (0.50) | CSNK2A1PDPK1JAK2FLT3CHEK1 | |
| Hydrochloric Acid SCHEMBL11516790 | 0.69 | PABPC1 (0.48) | CSNK2A1PDPK1JAK2FLT3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |