Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | TYMS | P04818 | 3/20 | 0.39 |
| ▸ | DAO | P14920 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | DDO | Q99489 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550534 | 0.84 | PDE3B (0.44) | PDE3BPDE3ATYMSDAOPARP1 | |
| SCHEMBL7550176 | 0.84 | CHEK1 (0.38) | PDE3BPDE3ATYMSKDM4EBACE1 | |
| SCHEMBL7547477 | 0.82 | KDM4E (0.44) | PDE3BPDE3APARP1KDM4ECYP1A2 | |
| SCHEMBL7549332 | 0.76 | CSNK2A1 (0.33) | PDE3BPDE3ACYP1A2 | |
| SCHEMBL7545063 | 0.73 | CSNK2A1 (0.35) | CYP1A2 | |
| SCHEMBL7504185 | 0.70 | DAO (0.36) | PDE3BPDE3ATYMSDAOPARP1 | |
| SCHEMBL8872919 | 0.67 | KDM4E (0.47) | PDE3BPDE3ADAOKDM4EBACE1 | |
| SCHEMBL27171556 | 0.65 | ERN1 (0.43) | PDE3BPDE3ADAOKDM4EBACE1 | |
| SCHEMBL30984913 | 0.64 | DAO (0.44) | TYMSDAOPARP1KDM4EMAPT | |
| SCHEMBL29655244 | 0.63 | ALDH1A1 (0.56) | TYMSDAOPARP1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931081-B1 | PYRIDAZINO 4,5-B]-QUINOLINE 5-OXIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS GLYCINE ANTAGONISTS | MERZ & CO GMBH & CO (DE) | 2002-09-25 | — | — | EP | claimed |