Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29834150 | 1.00 | KDM4E (0.43) | KDM4EALDH1A1KMT2ACOMTCHRM1 | |
| SCHEMBL31505059 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1KMT2ACOMTCHRM1 | |
| SCHEMBL2627824 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1KMT2ACOMTCHRM1 | |
| SCHEMBL5038676 | 0.81 | ALDH1A1 (0.44) | KDM4EALDH1A1KMT2ACOMTCHRM1 | |
| SCHEMBL1331870 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1KMT2ACOMTCHRM1 | |
| SCHEMBL16252854 | 0.77 | NOS3 (0.50) | KDM4EMETAP2L3MBTL1HSP90AA1SLC6A2 | |
| SCHEMBL15502005 | 0.76 | ALDH1A1 (0.42) | KDM4EALDH1A1KMT2ACOMTCHRM1 | |
| SCHEMBL25053731 | 0.75 | CA2 (0.37) | KDM4EALDH1A1KMT2ATSHRHTT | |
| SCHEMBL12293799 | 0.75 | MAPT (0.35) | KDM4EL3MBTL1HTTNOS3NOS1 | |
| SCHEMBL29724855 | 0.75 | DPP4 (0.36) | KDM4EALDH1A1KMT2AHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288130-B2 | Polypeptide cleavage process | MEDTRONIC, INC. (US) | 2012-10-16 | — | — | US | claimed |
| EP-1532142-B1 | POLYPEPTIDE CLEAVAGE PROCESS | MEDTRONIC INC (US) | 2012-03-21 | — | — | EP | claimed |
| US-20100311947-A1 | POLYPEPTIDE CLEAVAGE PROCESS | MEDTRONIC, INC. (US) | 2010-12-09 | — | — | US | claimed |
| EP-1531836-B1 | POLYPEPTIDE CLEAVAGE PROCESS | MEDTRONIC INC (US) | 2010-11-10 | — | — | EP | claimed |
| US-7771966-B2 | Polypeptide cleavage process | MEDTRONIC, INC. (US) | 2010-08-10 | — | — | US | claimed |
| US-7592432-B2 | selectively splitting the polypeptide at a Cys-His site, by hydrolysis in presence of a palladium promotor dissolved in formic acid; purification with by-product inhibition | RESTORAGEN, INC. (US) | 2009-09-22 | — | — | US | claimed |
| EP-1531836-A4 | POLYPEPTIDE CLEAVAGE PROCESS | RESTORAGEN INC (US) | 2008-11-05 | — | — | EP | claimed |
| EP-1532142-A4 | POLYPEPTIDE CLEAVAGE PROCESS | RESTORAGEN INC (US) | 2007-08-08 | — | — | EP | claimed |
| US-20050227313-A1 | Polypeptide cleavage process | MEDTRONIC, INC. | 2005-10-13 | — | — | US | claimed |
| US-20050227314-A1 | Polypeptide cleavage process | MEDTRONIC, INC. | 2005-10-13 | — | — | US | claimed |
| EP-1532142-A2 | POLYPEPTIDE CLEAVAGE PROCESS | Restoragen, Inc. (US) | 2005-05-25 | — | — | EP | claimed |
| EP-1531836-A2 | POLYPEPTIDE CLEAVAGE PROCESS | Restoragen, Inc. (US) | 2005-05-25 | — | — | EP | claimed |
| WO-2004011599-A2 | POLYPEPTIDE CLEAVAGE PROCESS | RESTORAGEN, INC. (US) | 2004-02-05 | — | — | WO | claimed |
| WO-2003100015-A2 | POLYPEPTIDE CLEAVAGE PROCESS | RESTORAGEN, INC. (US) | 2003-12-04 | — | — | WO | claimed |
| CN-114878540-A | Derivatization reagents, kits and methods for detecting nerve agents | 中国人民解放军军事科学院军事医学研究院 | 2022-08-09 | — | — | CN | disclosed |
| EP-1668021-B1 | NOVEL THIOXYLOSE COMPOUNDS, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USE THEREOF IN THERAPEUTICS | FOURNIER LAB SA (FR) | 2011-06-22 | — | — | EP | disclosed |
| US-7470671-B2 | Thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therapeutics | LABORATOIRE FOURNIER (FR) | 2008-12-30 | — | — | US | disclosed |
| US-20070054955-A1 | Novel thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therepeutics. | LABORATOIRES FOURNIER S.A. (FR) | 2007-03-08 | — | — | US | disclosed |
| EP-1668021-A2 | NOVEL THIOXYLOSE COMPOUNDS, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USE THEREOF IN THERAPEUTICS | LABORATOIRES FOURNIER S.A. (FR) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030785-A2 | NOVEL THIOXYLOSE COMPOUNDS, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USE THEREOF IN THERAPEUTICS | LABORATOIRES FOURNIER S.A. (FR) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054955-A1 | Novel thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therepeutics. | NOTUM, STS, AGPS | KDM4E 1350/4885ALDH1A1 878/4885KMT2A 4016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.