Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.80 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.80 |
| ▸ | CA9 | Q16790 | 6/20 | 0.74 |
| ▸ | CA1 | P00915 | 5/20 | 0.74 |
| ▸ | CA2 | P00918 | 5/20 | 0.74 |
| ▸ | CA4 | P22748 | 4/20 | 0.74 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316300 | 0.90 | CA9 (0.72) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL8317861 | 0.89 | PTGS2 (1.00) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL8121437 | 0.84 | CA9 (0.67) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL6339325 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL6342192 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL4187519 | 0.81 | CA1 (0.58) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL8636808 | 0.81 | PTGS2 (0.74) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL8317163 | 0.81 | PTGS2 (0.84) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL8317359 | 0.81 | PTGS2 (0.83) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL6349532 | 0.80 | PTGS2 (0.69) | PTGS2PTGS1CA9CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731795-B1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1999-12-22 | — | — | EP | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |