Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 15/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141067 | 0.80 | LTA4H (0.67) | LTA4HMEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL7141071 | 0.77 | LTA4H (0.92) | LTA4H | |
| SCHEMBL7552353 | 0.75 | LTA4H (0.64) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13588339 | 0.75 | LTA4H (1.00) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10829172 | 0.74 | LTA4H (0.69) | LTA4HMEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL7139497 | 0.74 | LTA4H (1.00) | LTA4H | |
| SCHEMBL570564 | 0.73 | L3MBTL1 (0.70) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4531624 | 0.73 | LTA4H (1.00) | LTA4H | |
| SCHEMBL7440978 | 0.73 | L3MBTL1 (0.69) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7132938 | 0.72 | LTA4H (0.84) | LTA4HACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1221441-A2 | LTA4 Hydrolase inhibitors | G.D. SEARLE & CO. (US) | 2002-07-10 | — | — | EP | disclosed |
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |