Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | CCR2 | P41597 | 3/20 | 0.48 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6541445 | 0.95 | CXCR4 (0.55) | CXCR4OPRL1CCR2 | |
| SCHEMBL6541449 | 0.95 | CXCR4 (0.55) | CXCR4OPRL1CCR2 | |
| SCHEMBL11419710 | 0.87 | KDM4E (0.59) | CXCR4KDM4E | |
| SCHEMBL11462791 | 0.86 | CCR2 (0.49) | CCR2SPHK2SPHK1 | |
| SCHEMBL11459718 | 0.82 | CCR2 (0.49) | CCR2SPHK2SPHK1 | |
| SCHEMBL7454601 | 0.82 | OPRD1 (0.52) | CCR2 | |
| SCHEMBL16293069 | 0.81 | CXCR4 (0.47) | CXCR4OPRL1CCR2SPHK2SPHK1 | |
| SCHEMBL14454201 | 0.81 | CCR2 (0.48) | CCR2SPHK2SPHK1 | |
| SCHEMBL13220244 | 0.80 | CXCR4 (0.50) | CXCR4 | |
| SCHEMBL19946919 | 0.79 | CCR2 (0.61) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137412-A4 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1137412-A2 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000033788-A2 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES INC. (US) | 2000-06-15 | — | — | WO | disclosed |