Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7552071 | 1.00 | CHEK1 (0.60) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8583955 | 0.86 | NTRK1 (0.57) | CHEK1NTRK1PAK1DHFRKDR | |
| SCHEMBL8583949 | 0.86 | NTRK1 (0.57) | CHEK1NTRK1PAK1DHFRKDR | |
| SCHEMBL7600606 | 0.85 | CHEK1 (0.59) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7600600 | 0.85 | CHEK1 (0.59) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7551548 | 0.84 | CHEK1 (0.60) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7551557 | 0.84 | CHEK1 (0.60) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8530485 | 0.83 | DHFR (0.42) | CHEK1NTRK1PAK1PDK1DHFR | |
| SCHEMBL7552840 | 0.81 | CHEK1 (0.66) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7552833 | 0.81 | CHEK1 (0.66) | CHEK1CHEK2CDK1SRCCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715628-B1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA SPA (IT) | 2002-10-02 | — | — | EP | claimed |