Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.41 |
| ▸ | TLK2 | Q86UE8 | 6/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8585839 | 0.85 | TLK2 (0.49) | TLK2PDK1PAK1 | |
| SCHEMBL7552071 | 0.83 | CHEK1 (0.60) | DHFRNTRK1TLK2PDK1CHEK1 | |
| SCHEMBL7552077 | 0.83 | CHEK1 (0.60) | DHFRNTRK1TLK2PDK1CHEK1 | |
| SCHEMBL8528465 | 0.83 | DHFR (0.42) | DHFRNTRK1TLK2CHEK1PAK4 | |
| SCHEMBL8583955 | 0.81 | NTRK1 (0.57) | DHFRNTRK1CHEK1PAK1 | |
| SCHEMBL8583949 | 0.81 | NTRK1 (0.57) | DHFRNTRK1CHEK1PAK1 | |
| SCHEMBL8614775 | 0.81 | NTRK1 (0.44) | NTRK1TLK2PDK1CHEK1 | |
| SCHEMBL8527884 | 0.80 | AKT2 (0.58) | TLK2PDK1 | |
| SCHEMBL8590004 | 0.80 | TLK2 (0.41) | NTRK1TLK2PDK1CHEK1PAK1 | |
| SCHEMBL8530158 | 0.80 | RET (0.45) | DHFRNTRK1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | claimed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | claimed |
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | disclosed |
| EP-0752985-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-15 | — | — | EP | disclosed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | disclosed |