Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.32 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Ethoxyethanol SCHEMBL8613682 | 0.89 | ALDH1A1 (0.74) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL2231058 | 0.87 | — | — | |
| SCHEMBL17029461 | 0.85 | MEN1 (0.52) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL15264130 | 0.85 | MEN1 (0.52) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL18364665 | 0.85 | MEN1 (0.52) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL29002323 | 0.83 | MEN1 (0.50) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL15836190 | 0.83 | TSHR (0.56) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Dimethylamine SCHEMBL7124815 | 0.83 | TSHR (0.46) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL4067863 | 0.81 | TSHR (0.77) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL11143375 | 0.81 | TSHR (0.77) | TSHRMAPK1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103333315-B | Preparation method of modified polyurethane used for printing ink | Shantou donghe machinery co ltd | 2015-04-08 | — | — | CN | claimed |
| CN-103333315-B | Preparation method of modified polyurethane used for printing ink | Shantou donghe machinery co ltd | 2015-04-08 | — | — | CN | disclosed |
| EP-0865437-B1 | ISOMALEIMIDES AND POLYMERS DERIVED THEREFROM | MINNESOTA MINING & MFG (US) | 2002-07-03 | — | — | EP | disclosed |
| EP-0865437-A1 | ISOMALEIMIDES AND POLYMERS DERIVED THEREFROM | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5744574-A | MIXING (POLY)MALEAMIC ACID WITH ACID HALIDE ; THEN TERTIARY AMINE; LOW TEMPERATURE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1998-04-28 | — | — | US | disclosed |
| WO-1997020832-A1 | ISOMALEIMIDES AND POLYMERS DERIVED THEREFROM | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-06-12 | — | — | WO | disclosed |