Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 8/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7552014 | 0.91 | RPS6KA5 (0.45) | RPS6KA5RPS6KB1CDK2ROCK1DYRK1A | |
| SCHEMBL7160121 | 0.88 | NPC1 (0.53) | RPS6KA5NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL7155951 | 0.85 | NPC1 (0.40) | RPS6KA5NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL7549611 | 0.81 | CYP1A2 (0.40) | RPS6KA5NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7159437 | 0.81 | NPC1 (0.42) | RPS6KA5NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL7551086 | 0.81 | KDM4E (0.40) | RPS6KA5NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL7555014 | 0.80 | KDM4E (0.60) | RPS6KA5RPS6KB1CDK2ROCK1DYRK1A | |
| SCHEMBL7160069 | 0.78 | KDM4E (0.37) | NPC1MAPTRAB9AALDH1A1KDM4E | |
| SCHEMBL7550136 | 0.78 | RPS6KA5 (0.46) | RPS6KA5RPS6KB1CDK2ROCK1DYRK1A | |
| SCHEMBL7153857 | 0.74 | PKM (0.50) | NPC1MAPTRAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020099054-A1 | 2-phenyl benzimidazole derivatives as MCP-1 antagonists | WARNER-LAMBERT COMPANY (US) | 2002-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099054-A1 | 2-phenyl benzimidazole derivatives as MCP-1 antagonists | CCR1, CCR2, CCR8 | RPS6KA5 3324/4885RPS6KB1 2087/4885CDK2 1886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.