Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.82 |
| ▸ | MEN1 | O00255 | 4/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.82 |
| ▸ | GAA | P10253 | 4/20 | 0.82 |
| ▸ | GLA | P06280 | 3/20 | 0.82 |
| ▸ | MAPT | P10636 | 3/20 | 0.82 |
| ▸ | GFER | P55789 | 1/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.80 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.80 |
| ▸ | IL4 | P05112 | 1/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31139657 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL7505116 | 0.89 | KDM4E (0.84) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL31139650 | 0.88 | KDM4E (0.81) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL29331870 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL3371543 | 0.84 | ADORA1 (0.89) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL7553240 | 0.84 | KDM4E (0.76) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL7509621 | 0.81 | KDM4E (0.71) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL7510328 | 0.81 | KDM4E (0.71) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL31139643 | 0.80 | ADORA2A (0.88) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL31139647 | 0.80 | ADORA1 (1.00) | KDM4EALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043621-B2 | Small molecule inhibitors of Interleukin-4 | TRUSTEES OF BOSTON UNIVERSITY (US) | 2024-07-23 | — | — | US | disclosed |
| US-20210317114-A1 | SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4 | TRUSTEES OF BOSTON UNIVERSITY (US) | 2021-10-14 | — | — | US | disclosed |
| WO-2021188871-A1 | SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4 | TRUSTEES OF BOSTON UNIVERSITY (US) | 2021-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12043621-B2 | Small molecule inhibitors of Interleukin-4 | IL4, IL2, IL4I1 | KDM4E 586/4885ALDH1A1 3144/4885MEN1 3952/4885 |
| US-20210317114-A1 | SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4 | IL4, IL2, IL4I1 | KDM4E 586/4885ALDH1A1 3144/4885MEN1 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.