Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GPR4 | P46093 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10217564 | 0.74 | GPR119 (0.42) | GPR119KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL7544915 | 0.74 | PDK4 (0.48) | KDM4EGPR4 | |
| SCHEMBL31487760 | 0.73 | GPR119 (0.47) | GPR119KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL2272318 | 0.73 | ALDH1A1 (0.56) | GPR119KDM4EALDH1A1MAPTTHRB | |
| SCHEMBL10217563 | 0.73 | GPR119 (0.41) | GPR119ALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL31487766 | 0.72 | GPR119 (0.48) | GPR119KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL14239665 | 0.72 | KDM4E (0.51) | GPR119KDM4EMAPTTHRBIGF1R | |
| SCHEMBL31167715 | 0.72 | KMT2A (0.51) | GPR119KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL20281515 | 0.72 | PDE4B (0.55) | GPR119KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30852111 | 0.72 | KDM4E (0.48) | GPR119KDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171122-A4 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1171122-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| WO-2000059502-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |