Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.57 |
| ▸ | DRD3 | P35462 | 5/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14507218 | 0.81 | ESR1 (0.42) | DRD2DRD3HSD17B10ALDH1A1KDM4E | |
| SCHEMBL4263745 | 0.80 | DRD2 (0.64) | DRD2DRD3OPRK1MAPTNFKB1 | |
| Bromide SCHEMBL7200937 | 0.78 | DRD2 (0.62) | DRD2DRD3OPRK1MAPTNFKB1 | |
| SCHEMBL10878783 | 0.73 | DRD2 (0.55) | DRD2DRD3OPRK1MAPTNFKB1 | |
| SCHEMBL14507279 | 0.73 | DRD2 (0.74) | DRD2DRD3DRD1 | |
| SCHEMBL31681697 | 0.73 | DRD2 (1.00) | DRD2DRD3MAPTNFKB1THPO | |
| SCHEMBL11981410 | 0.73 | DRD2 (1.00) | DRD2DRD3MAPTNFKB1THPO | |
| SCHEMBL265580 | 0.73 | DRD2 (1.00) | DRD2DRD3MAPTNFKB1THPO | |
| SCHEMBL3318587 | 0.73 | DRD2 (1.00) | DRD2DRD3MAPTNFKB1THPO | |
| SCHEMBL7554445 | 0.72 | DRD2 (0.63) | DRD2DRD3OPRK1MAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970042-B1 | 5-HYDROXYMETHYL-2-AMINOTETRALINS AS CARDIOVASCULAR AGENTS | ZAMBON SPA (IT) | 2002-01-09 | — | — | EP | disclosed |
| US-6063964-A | 5-hydroxymethyl-2-aminotetralins as cardiovascular agents | ZAMBON GROUP S.P.A. (IT) | 2000-05-16 | — | — | US | disclosed |
| EP-0970042-A1 | 5-HYDROXYMETHYL-2-AMINOTETRALINS AS CARDIOVASCULAR AGENTS | ZAMBON GROUP S.p.A. (IT) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998038155-A1 | 5-HYDROXYMETHYL-2-AMINOTETRALINS AS CARDIOVASCULAR AGENTS | ZAMBON GROUP S.P.A. (IT) | 1998-09-03 | — | — | WO | disclosed |