Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 4/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | PYGL | P06737 | 11/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547700 | 1.00 | GRIK1 (0.45) | GRIK1GRIK2NOS2NOS3NOS1 | |
| SCHEMBL7547697 | 1.00 | GRIK1 (0.45) | GRIK1GRIK2NOS2NOS3NOS1 | |
| SCHEMBL18934388 | 0.84 | GRIK1 (0.43) | GRIK1GRIK2NOS2 | |
| SCHEMBL18926591 | 0.84 | GRIK1 (0.43) | GRIK1GRIK2NOS2 | |
| SCHEMBL7549408 | 0.82 | AAK1 (0.41) | GRIK1GRIK2AAK1 | |
| SCHEMBL7549401 | 0.82 | AAK1 (0.41) | GRIK1GRIK2AAK1 | |
| SCHEMBL7553195 | 0.81 | PIN1 (0.40) | AAK1PTGS2 | |
| SCHEMBL7550970 | 0.81 | PIN1 (0.40) | AAK1PTGS2 | |
| SCHEMBL7550965 | 0.81 | PIN1 (0.40) | AAK1PTGS2 | |
| SCHEMBL7547375 | 0.80 | KDM4E (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| US-6337351-B1 | AROMATIC OLEFIN AMINES | TARGACEPT, INC. | 2002-01-08 | — | — | US | disclosed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | disclosed |