Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | EPOR | P19235 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550965 | 1.00 | PIN1 (0.40) | PIN1PTGS1PTGS2NFE2L2NR1H4 | |
| SCHEMBL7550970 | 1.00 | PIN1 (0.40) | PIN1PTGS1PTGS2NFE2L2NR1H4 | |
| SCHEMBL7547697 | 0.81 | GRIK1 (0.45) | PTGS2AAK1 | |
| SCHEMBL7554007 | 0.81 | GRIK1 (0.45) | PTGS2AAK1 | |
| SCHEMBL7547700 | 0.81 | GRIK1 (0.45) | PTGS2AAK1 | |
| SCHEMBL3325118 | 0.80 | CHRNB2 (0.49) | PTGS1PTGS2NFE2L2 | |
| SCHEMBL3325125 | 0.80 | CHRNB2 (0.49) | PTGS1PTGS2NFE2L2 | |
| SCHEMBL7549401 | 0.79 | AAK1 (0.41) | NR1H4AAK1 | |
| SCHEMBL7549408 | 0.79 | AAK1 (0.41) | NR1H4AAK1 | |
| SCHEMBL3322749 | 0.78 | MMP13 (0.34) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214288-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Targacept Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017943-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2001-03-15 | — | — | WO | disclosed |