Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 8/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7544532 | 0.88 | HTR1A (1.00) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7881150 | 0.84 | HTR1A (0.90) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7549298 | 0.81 | HTR1A (1.00) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7881295 | 0.81 | HTR1A (0.81) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7885642 | 0.79 | HTR1A (0.72) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7883009 | 0.79 | HTR1A (0.72) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7876565 | 0.78 | HTR1A (0.72) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7887563 | 0.78 | HTR1A (0.72) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7876610 | 0.78 | HTR1A (0.75) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7884119 | 0.76 | HTR1A (0.73) | HTR1ASLC6A4ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002543079-A | — | — | 2002-12-17 | — | — | JP | claimed |
| EP-1171439-A1 | AZAINDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-01-16 | — | — | EP | claimed |
| US-6337336-B1 | HETEROCYCLIC OXYPHENOL COMPOUNDS | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-08 | — | — | US | claimed |
| WO-2000064898-A1 | AZAINDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-02 | — | — | WO | claimed |
| EP-1171439-A1 | AZAINDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6337336-B1 | HETEROCYCLIC OXYPHENOL COMPOUNDS | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-08 | — | — | US | disclosed |
| WO-2000064898-A1 | AZAINDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-02 | — | — | WO | disclosed |