Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 8/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.78 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.78 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.45 |
| ▸ | PRKACA | P17612 | 3/20 | 0.45 |
| ▸ | CLK2 | P49760 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554088 | 0.88 | HTR1A (1.00) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7549298 | 0.84 | HTR1A (1.00) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL13502652 | 0.78 | SIGMAR1 (0.68) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL1849516 | 0.75 | SIGMAR1 (0.73) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7549308 | 0.74 | HTR1A (0.59) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL1853604 | 0.74 | SIGMAR1 (0.69) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL2064431 | 0.74 | SLC6A4 (0.64) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL1850315 | 0.72 | TMEM97 (0.63) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL13064304 | 0.72 | TMEM97 (0.59) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL7885535 | 0.71 | HTR1A (0.60) | HTR1ASLC6A4ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002543079-A | — | — | 2002-12-17 | — | — | JP | claimed |
| EP-1171439-A1 | AZAINDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-01-16 | — | — | EP | claimed |
| US-6337336-B1 | HETEROCYCLIC OXYPHENOL COMPOUNDS | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-08 | — | — | US | claimed |
| WO-2000064898-A1 | AZAINDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-02 | — | — | WO | claimed |
| EP-1171439-A1 | AZAINDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6337336-B1 | HETEROCYCLIC OXYPHENOL COMPOUNDS | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-08 | — | — | US | disclosed |
| WO-2000064898-A1 | AZAINDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-02 | — | — | WO | disclosed |