Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7560746 | 0.81 | KDM4E (0.46) | MAPTRAB9ANPC1GAAKDM4E | |
| SCHEMBL16784518 | 0.72 | MEN1 (0.73) | MAPTRAB9ANPC1GAAKDM4E | |
| SCHEMBL7517550 | 0.71 | MAPT (0.50) | MAPTRAB9ANPC1GAAKDM4E | |
| SCHEMBL39057 | 0.70 | MAPT (1.00) | MAPTRAB9ANPC1GAAKDM4E | |
| SCHEMBL1459772 | 0.70 | MAPT (1.00) | MAPTRAB9ANPC1GAAKDM4E | |
| SCHEMBL486240 | 0.69 | RECQL (0.74) | MAPTGAAKDM4EL3MBTL1RECQL | |
| SCHEMBL19409875 | 0.68 | MAPT (0.61) | MAPTRAB9ANPC1GAAKDM4E | |
| SCHEMBL11056727 | 0.65 | MAPT (0.55) | MAPTRAB9ANPC1GAAKDM4E | |
| SCHEMBL1921511 | 0.64 | MAPT (0.85) | MAPTRAB9ANPC1GAAKDM4E | |
| SCHEMBL12648780 | 0.64 | MAPT (0.85) | MAPTRAB9ANPC1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |