Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7528545 | 0.81 | KDM4E (0.58) | MAPTRAB9AMAPK1KDM4ENPC1 | |
| SCHEMBL7520380 | 0.78 | MT-CO2 (0.51) | MAPTGAARAB9AMAPK1KDM4E | |
| SCHEMBL7518230 | 0.78 | KDM4E (0.40) | MAPTGAARAB9AKDM4ENPC1 | |
| SCHEMBL7517596 | 0.78 | ALDH1A1 (0.54) | MAPTRAB9AMAPK1KDM4ENPC1 | |
| SCHEMBL7524044 | 0.74 | KIF11 (0.40) | MAPTKDM4EMEN1KMT2ACA1 | |
| SCHEMBL16784518 | 0.72 | MEN1 (0.73) | MAPTGAARAB9AMAPK1KDM4E | |
| SCHEMBL30692648 | 0.71 | CA1 (0.48) | MAPTMAPK1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL7554347 | 0.71 | MAPT (0.50) | MAPTGAARAB9AMAPK1KDM4E | |
| SCHEMBL1459772 | 0.70 | MAPT (1.00) | MAPTGAARAB9AMAPK1KDM4E | |
| SCHEMBL39057 | 0.70 | MAPT (1.00) | MAPTGAARAB9AMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111675715-B | Difuranopyridine derivative and preparation method thereof | 江苏建筑职业技术学院 | 2022-10-18 | — | — | CN | disclosed |
| CN-111675715-A | Difuranopyridine derivative and preparation method thereof | 江苏建筑职业技术学院 | 2020-09-18 | — | — | CN | disclosed |
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |