Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7660416 | 0.82 | P2RX7 (0.58) | P2RX7ABCB11MEN1ALDH1A1KMT2A | |
| SCHEMBL7667240 | 0.81 | P2RX7 (0.47) | P2RX7ABCB11MEN1ALDH1A1KMT2A | |
| SCHEMBL7555242 | 0.78 | HRH3 (0.45) | MEN1KMT2A | |
| SCHEMBL7660361 | 0.77 | EPHX2 (0.54) | P2RX7ABCB11MEN1ALDH1A1KMT2A | |
| SCHEMBL6941223 | 0.76 | P2RX7 (0.70) | P2RX7ABCB11GPR55CA12CA9 | |
| SCHEMBL13958658 | 0.73 | P2RX7 (0.55) | P2RX7 | |
| SCHEMBL13958670 | 0.73 | P2RX7 (0.55) | P2RX7 | |
| SCHEMBL6939157 | 0.73 | P2RX7 (0.82) | P2RX7 | |
| SCHEMBL6939826 | 0.73 | P2RX7 (0.68) | P2RX7ABCB11ALDH1A1GPR55 | |
| Hydrochloric Acid SCHEMBL4509750 | 0.72 | P2RX7 (0.54) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492355-B1 | Adamantane derivatives | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | claimed |
| US-6492355-B1 | Adamantane derivatives | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1171432-A1 | ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061569-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |