Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 6/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986724 | 0.93 | FLT1 (0.46) | FLT1FLT4KDRCNR1HCRTR1 | |
| SCHEMBL7987156 | 0.92 | KDR (0.46) | FLT1FLT4KDRCNR1CNR2 | |
| SCHEMBL7508991 | 0.92 | CNR1 (0.51) | FLT1FLT4KDRCNR1CNR2 | |
| SCHEMBL7976639 | 0.92 | FLT1 (0.47) | FLT1FLT4KDRCNR1CNR2 | |
| SCHEMBL7551283 | 0.88 | KDR (0.49) | FLT1FLT4KDRNR3C1TP53 | |
| SCHEMBL7555418 | 0.88 | KDR (0.47) | FLT1FLT4KDRNR3C1 | |
| SCHEMBL7990656 | 0.88 | CYP1A2 (0.48) | FLT1FLT4KDRCNR1CNR2 | |
| SCHEMBL7513681 | 0.87 | KDR (0.65) | FLT1FLT4KDRCNR1CNR2 | |
| SCHEMBL7993627 | 0.85 | KDR (0.45) | FLT1FLT4KDRSMN1; SMN2 | |
| SCHEMBL7554912 | 0.84 | KDR (0.50) | FLT1FLT4KDRCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |